ncRNA name | OGT siRNA |
ncRNA Category | siRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human retinal microvascular endothelial cells (HRECs) |
Methods | Western blot, siRNA transfection, qRT-PCR, flow cytometry |
Expression pattern | associated |
Functional description | The reduction of O-GlcNAcylation following infection with OGT siRNA, exacerbated the production of ROS and decreased the expression of antioxidant genes. Treatment with PUGNAc reduced glyoxal-induced cell apoptosis and transfection with OGT siRNA increased HREC apoptosis. |
PubMed ID | 26311324 |
Year | 2015 |
Title | The augmentation of O-GlcNAcylation reduces glyoxal-induced cell injury by attenuating oxidative stress in human retinal microvascular endothelial cells. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.